PMID- 8264519
OWN - NLM
STAT- MEDLINE
DCOM- 19940124
LR  - 20131121
IS  - 0378-0392 (Print)
IS  - 0378-0392 (Linking)
VI  - 19
IP  - 4-5
DP  - 1993
TI  - Clinical manifestations of magnesium deficiency.
PG  - 314-22
AB  - Magnesium (Mg) is critical for the function of numerous enzyme systems. Mg 
      deficiency thereby may result in many and varied clinical manifestations. Mg 
      deficiency is common as approximately 10% of patients admitted to city hospitals 
      are hypomagnesemic. Mg deficiency is usually due to losses from the 
      gastrointestinal tract or from the kidney. A serum Mg concentration of < 1.5 
      mEq/l usually indicates Mg deficiency, however, intracellular Mg deletion may be 
      present despite a normal serum Mg concentration. Acute clinical manifestations of 
      Mg deficiency include neuromuscular hyperexcitability, cardiac arrhythmias, and 
      biochemical abnormalities of hypokalemia and hypocalcemia. Chronic Mg depletion 
      may contribute to hypertension, atherosclerotic vascular disease, altered glucose 
      homeostasis, and metabolic bone disease. Therapy of the acute manifestations 
      usually requires parenteral Mg administration of 24-48 mEq Mg/day for 3-5 days. 
      Long-term Mg repletion may be accomplished by the administration of 300-600 mg of 
      Mg orally/day.
FAU - Abbott, L G
AU  - Abbott LG
AD  - Department of Endocrinology, LAC+USC Medical Center, Los Angeles 90033.
FAU - Rude, R K
AU  - Rude RK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Switzerland
TA  - Miner Electrolyte Metab
JT  - Mineral and electrolyte metabolism
JID - 7802196
RN  - I38ZP9992A (Magnesium)
SB  - IM
MH  - Humans
MH  - Magnesium/administration & dosage/physiology/therapeutic use
MH  - Magnesium Deficiency/*diagnosis/drug therapy/etiology/metabolism/physiopathology
RF  - 67
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
PST - ppublish
SO  - Miner Electrolyte Metab. 1993;19(4-5):314-22.