Wisdom Panel

For Breeders
Planning to breed a cat with this genetic variant?
There are many responsibilities to consider when breeding cats. Regardless of test results it is important that your cat is in good general health and that you are in a position to care for the kittens if new responsible owners are not found. For first time or novice breeders, advice can be found at most cat registry websites.
This condition is autosomal recessive, asymptomatic, meaning that cats with two copies of the variant will show the variant-associated condition but will not suffer disease due to this genetic cause. Current understanding is that a cat with one or two copies of the Factor XII Deficiency variant can be safely bred with a cat with zero, one or two copies of the variant. Please note: It is possible that clinical signs similar to the ones caused by the Factor XII Deficiency mutation could develop due to a different genetic or clinical cause.


Technical Details
Gene	F12
Variant	Deletion
Chromosome	A1
Coordinate Start	175,381,114
Coordinate End	175,381,113
All coordinates reference FelCat9.0 

References & Credit
Credit to our scientific colleagues:
Bender, D. E., Kloos, M. T., Pontius, J. U., Hinsdale, M. E., & Bellinger, D. A. (2015). Molecular Characterization of Cat Factor XII Gene and Identification of a Mutation Causing Factor XII Deficiency in a Domestic Shorthair Cat Colony. Veterinary Pathology, 52(2), 312–320. View the article
Maruyama, H., Brooks, M. B., Stablein, A., & Frye, A. (2019). Factor XII deficiency is common in domestic cats and associated with two high frequency F12 mutations. Gene, 706, 6–12. View the article