%PDF-1.7
%
379 0 obj
<>
endobj
368 0 obj
<>
endobj
378 0 obj
<>stream
Acrobat Distiller 8.1.0 (Windows)
Arbortext Advanced Print Publisher 9.1.440/W Unicode
2021-05-20T06:15:08-07:00
2020-09-21T14:36:39+08:00
2021-05-20T06:15:08-07:00
uuid:2c7455db-5f8a-49d6-b57f-0ebb41a35f0d
uuid:f30dec51-1dd1-11b2-0a00-38003851aaff
application/pdf
Science Journals — AAAS
endstream
endobj
365 0 obj
<>
endobj
2 0 obj
<>
endobj
367 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/Thumb 362 0 R/Type/Page>>
endobj
1 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/Properties<>/XObject<>>>/Rotate 0/Thumb 3 0 R/Type/Page>>
endobj
38 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/Properties<>/XObject<>>>/Rotate 0/Thumb 39 0 R/Type/Page>>
endobj
57 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/Properties<>/XObject<>>>/Rotate 0/Thumb 58 0 R/Type/Page>>
endobj
70 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/Properties<>/XObject<>>>/Rotate 0/Thumb 71 0 R/Type/Page>>
endobj
325 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/Thumb 326 0 R/Type/Page>>
endobj
337 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/Thumb 338 0 R/Type/Page>>
endobj
449 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>>
endobj
476 0 obj
[482 0 R 483 0 R 484 0 R 485 0 R 486 0 R 487 0 R 488 0 R 489 0 R 490 0 R 491 0 R]
endobj
477 0 obj
<>stream
q
87.5 0 0 21.75 72 662.25 cm
/Im0 Do
Q
BT
/T1_0 1 Tf
10 0 0 10 72 622 Tm
(Distinct conformational states of SARS-CoV-2 spike protein)Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 72 600.99997 Tm
(Rits-Volloch and Bing Chen)Tj
0 1 TD
(Yongfei Cai, Jun Zhang, Tianshu Xiao, Hanqin Peng, Sarah M. Sterling, Ri\
chard M. Walsh Jr., Shaun Rawson, Sophia)Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 182.28796 554.99997 Tm
(originally published online July 21, 2020)Tj
-13.786 0 Td
(DOI: 10.1126/science.abd4251)Tj
5.50301 1 Td
( \(6511\), 1586-1592.)Tj
/T1_0 1 Tf
-1.668 0 Td
(369)Tj
/T1_2 1 Tf
-3.83501 0 Td
(Science\240)Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 145.45605 466.99979 Tm
(, this issue p. 1586)Tj
/T1_2 1 Tf
-3.55701 0 Td
(Science)Tj
/T1_1 1 Tf
-3.125 1 Td
(function and could inform vaccine design.)Tj
0 1.00001 TD
(structures of both the prefusion and postfusion conformations. These str\
uctures add to our understanding of S protein )Tj
41.23291 1 Td
(electron microscopy)Tj
/T1_3 1 Tf
-0.54899 0 Td
(-)Tj
/T1_1 1 Tf
-40.68392 0 Td
(of the viral and host cell membranes. They purified full-length S protei\
n and determined cryo)Tj
14.67298 1.00001 Td
( now provide insight into the structural changes in the S protein that r\
esult in the fusion )Tj
/T1_2 1 Tf
-2.168 0 Td
(et al.)Tj
/T1_1 1 Tf
-12.50498 0 Td
(prefusion conformation. Cai )Tj
0 1 TD
(focused on the trimeric spike \(S\) protein. Several structures have sho\
wn a stabilized ectodomain of the spike in its )Tj
3.125 1 Td
(Efforts to protect human cells against severe acute respiratory syndrome\
coronavirus 2 \(SARS-CoV-2\) have)Tj
/T1_0 1 Tf
-3.125 1.00001 Td
(A dynamic viral spike)Tj
ET
BT
/T1_0 1 Tf
6 0 0 6 79 401 Tm
(ARTICLE TOOLS)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 187 399 Tm
(http://science.sciencemag.org/content/369/6511/1586)Tj
ET
BT
0 g
/T1_0 1 Tf
6 0 0 6 79 358.99997 Tm
(MATERIALS)Tj
0 1.00001 TD
(SUPPLEMENTARY )Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 187 363 Tm
(http://science.sciencemag.org/content/suppl/2020/07/20/science.abd4251.D\
C1)Tj
ET
BT
0 g
/T1_0 1 Tf
6 0 0 6 79 316.99997 Tm
(CONTENT)Tj
T*
(RELATED )Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 187 296.99991 Tm
(http://stm.sciencemag.org/content/scitransmed/12/554/eabc1126.full)Tj
0 1 TD
(http://stm.sciencemag.org/content/scitransmed/12/555/eabc9396.full)Tj
0 1.00001 TD
(http://stm.sciencemag.org/content/scitransmed/12/550/eabc3539.full)Tj
0 1 TD
(http://stm.sciencemag.org/content/scitransmed/12/549/eabb9401.full)Tj
ET
BT
0 g
/T1_0 1 Tf
6 0 0 6 79 281 Tm
(REFERENCES)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 187 270.99997 Tm
(http://science.sciencemag.org/content/369/6511/1586#BIBL)Tj
0 g
T*
(This article cites 58 articles, 22 of which you can access for free)Tj
ET
BT
/T1_0 1 Tf
6 0 0 6 79 245 Tm
(PERMISSIONS)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 187 243 Tm
(http://www.sciencemag.org/help/reprints-and-permissions)Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 193.38391 128 Tm
(Terms of Service)Tj
0 g
-15.17299 0 Td
(Use of this article is subject to the )Tj
ET
72 114 m
521 114 l
0 0 m
S
BT
ET
BT
/T1_1 1 Tf
8 0 0 8 357.45605 93.99997 Tm
( is a registered trademark of AAAS.)Tj
/T1_2 1 Tf
-3.55701 0 Td
(Science)Tj
/T1_1 1 Tf
-32.125 0 Td
(Science, 1200 New York Avenue NW, Washington, DC 20005. The title )Tj
3.83501 1 Td
(\(print ISSN 0036-8075; online ISSN 1095-9203\) is published by the Amer\
ican Association for the Advancement of)Tj
/T1_2 1 Tf
-3.83501 0 Td
(Science )Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 72 71.99997 Tm
(Science. No claim to original U.S. Government Works)Tj
T*
(Copyright \251 2020 The Authors, some rights reserved; exclusive license\
e American Association for the Advancement of)Tj
ET
BT
/T1_1 1 Tf
0 -8 8 0 575 320.2041 Tm
(on May 20, 2021)Tj
-0.278 0 Td
( )Tj
0 0 1 rg
-13.50598 0 Td
(http://science.sciencemag.org/)Tj
0 g
-8.11398 0 Td
(Downloaded from )Tj
ET
endstream
endobj
481 0 obj
<>/Filter/FlateDecode/Height 87/Length 19684/Name/X/Subtype/Image/Type/XObject/Width 350>>stream
HyTS߽Ia
"6p\P縠x:Z.Suk:8ud,EԺУ:xtSVk9@na}/ Ҟ6Gy@{_rcL"bFSgjz"UH}>2Z
5f @a,uWP24
jѨ\i-~==Op(rw]EQڇMyƧH4E5(HQ_-*P1.#*kb"f_+XA¾ՆK$FxUFJeFq {vdcg8ZS#3_kX `9'p (3u_Od}uvn|TSI#
!y 3|].Fh{U_JA-M0bD22}[-(U~[yTk|H mL;ƶc 0X ?1Ar?oƀU]C:/^ّ,7(a"Gq?b#QUaS L6)$Hm[ANc tPĎvURl2!VV{^e(^I9Dã3l]]\3$!i;v{?.Ҕ}31,ER[^k4Nok#b7fIȐy`au^GUĉ
W&\y,$d<|rD;VӪn>Mј[Mi#DQ LY2Cme#BV~2`ls~s W&
=xAJE^dɡ>S=`_dgk+gqaنKgbK=E[> @AQbg(